Mussel Adhesive Protein; Recombinant Mussel Adhesive Protein; MAPs; Marine Mussel Adhesion; Lyophilized hmoov; Kev daws

Khoom npe: Mussel Adhesive Protein; Recombinant mussel nplaum protein; MAPs; Marine Mussel Adhesion; Lyophilized hmoov; Kev daws

Product Information:

Mussel adhesive proteins (MAPs) yog cov proteins uas tau muab los ntawm Mytilus edulis, muaj npe nrov rau lawv cov khoom nplaum tshwj xeeb. Cov proteins no, nplua nuj nyob rau hauv 3,4-dihydroxyphenylalanine (DOPA) residues, pab kom mussels ua raws nraim rau qhov chaw nyob rau hauv ib puag ncig nyuaj. Vim muaj cov yam ntxwv tshwj xeeb ntawm biochemical thiab txhua yam khoom siv, MAPs tau nyiam qhov tseem ceeb hauv kev kho mob biomedical, muab cov ntawv cog lus zoo hauv kev kho mob, xa tshuaj, cov ntaub so ntswg engineering, thiab tshuaj pleev ib ce. Recombinant MAPs (rMAPs), tshwj xeeb tshaj yog, tuav lub peev xwm zoo vim lawv cov khoom muaj txiaj ntsig zoo, suav nrog antioxidant, tiv thaiv - mob, tshuaj tua kab mob, thiab kev tiv thaiv ntawm tes. Lawv tab tom tshawb nrhiav ntau ntxiv rau lawv lub luag haujlwm hauv kev kho cov ntaub so ntswg, rov tsim dua tshiab ntawm daim tawv nqaij, thiab cov phiaj xwm xa tshuaj.

Mussels, nrog lawv cov tawv byssal threads, tiv taus qhov cuam tshuam ntawm cov cua muaj zog thiab nthwv dej. Qhov kev txaus siab lom zem no tshwm sim los ntawm cov khoom tshwj xeeb uas zais los ntawm mussel lub caj pas byssal hu ua mussel nplaum protein.

Cov protein no nthuav tawm cov khoom nplaum zoo tshaj plaws hauv qab dej, muab nws lub peev xwm zoo rau kev kho mob lom.

Kev tshawb fawb tau pom tias mussel adhesive protein yog nplua nuj nyob rau hauv zoo nqi amino acids thiab dopa pawg; cov pab pawg raug them zoo tuaj yeem nyiam cov hlwb tsis zoo, pab txhawb kev txav chaw ntawm tes thiab kho qhov txhab; cov pab pawg dopa tsis tsuas yog muaj zog los tiv thaiv- mob thiab ua haujlwm antioxidant, tab sis kuj tuaj yeem tsim cov kab ke hauv microscopic network los ntawm tus kheej -crosslinking kom sai ua cov yeeb yaj kiab, tswj kev noj qab haus huv ntawm daim tawv nqaij barrier. Cov nplaum nplaum nplaum protein, nrog nws cov kev ua tau zoo thiab tsis tshua muaj, yog lub npe hu ua "dej hiav txwv kub". Txawm li cas los xij, cov tsiaj ib txwm muaj- cov txheej txheem muab tau los muaj cov txiaj ntsig qis thiab tsim cov khoom sib txawv thiab sib txawv, nrog rau kev pheej hmoo ntawm kev kis tus kab mob thiab kev tiv thaiv kab mob. Tam sim no, gihichem tau tsim dual -cov tub ntxhais platform sib txuas cov khoom siv hluav taws xob thiab cov kev txawj ntse los nthuav qhia cov kab laug sab adhesion protein noob ib ntu hauv microbial chassis. Recombinant proteins yog qhov ruaj khov thiab ua tau zoo, nrog rau txhua lub cubic fermentation tank muaj peev xwm hloov qhov kev rho tawm los ntawm ntau pua lab tus kab lis kev cai mussels, tawg los ntawm cov fwj ntawm loj -scale industrialization.

Peb qhov zoo:

1. Lub Ntiaj Teb Lub Siab Tshaj Lij Ntau Lawm Recombinant Mussel Adhesive Protein Strains

• Mussel protein boasts qhov siab tshaj plaws theoretical dopa ntsiab lus (44% los ntawm huab hwm coj, 28% los ntawm molar).
• Lub ntiaj teb kev tshaj tawm qib siab tshaj plaws ntawm cov noob caj noob ces rau mussel protein.
• Kev ywj pheej dub -box sequence optimization lub tswv yim.
• Tshwj xeeb siab - thev naus laus zis los ua ke.

2. Cim Tyrosinase Hloov Kho Tshuab

• Kev hloov kho tyrosinase tshwj xeeb thev naus laus zis tswj cov oxidation ntawm tyrosine pawg rau DOPA, zam dhau oxidation rau quinone.
• Precise tswj ntawm dopa cov ntsiab lus los ntawm enzyme kinetics.

3. Ntev-Lub Sij Hawm Stability Technology thiab Txheej Txheem

• Ntev -cov khoom lag luam ruaj khov: Tsis muaj xim tseem ceeb thaum lub sijhawm txee lub neej (daj tshwm sim tom qab oxidation rau quinone).
• Molecularly rational tsim thiab optimized formulation txheej txheem ua tiav ntev - lub sij hawm ruaj khov nyob rau hauv ob qho tib si khoom thiab kua theem.