Kuv. Glutathione: tus tub ntxhais molecule ntawm antoxidant system
Glutathione (glutathione, cas {{70-18-8) yog lub sam thiaj raug tsim los ntawm glutamic acid, cysteine thiab glycine. Nws muaj nyob hauv txhua tus neeg lub hlwb thiab yog lub npe hu ua "Tus Thawj Coj-hauv-tus thawjcoj tiv thaiv kab mob." Nws cov tub ntxhais lub zog muaj xws li:
1.Free radical scavenging:
Ncaj qha tsis pub muaj cov oxygen hom (Ros) thiab paintides, thiab txo qis oxidative kev puas tsuaj (FORAN LI AL., 2009);
2.regenation ntawm antioxidants:
Txo oxidized vitamin C thiab Vitamin E, tswj cov kev ua haujlwm hauv antioxidant (wu li al., 2004);
3.txim pov thawj lub tswv yim:
Ua ke nrog cov tshuaj metabolites thiab ib puag ncig cov co toxins los ntawm glutathione-s-hloov (GST li al., 2004);
4.immunomodulation:
Txhim kho qhov kev ua si ntawm cov neeg tua kab (xaws cov hlwb) (gutscher li al., 2008).
Ii. Liposomal Technology: Tus yuam sij rau kev txhim kho Bioavailability
Lub qhov ncauj tsoos glutathione muaj cov xyoob ntoo muaj tsawg dua 5% vim muaj cov pa roj acid untestinal thiab kev nqus nyiaj hauv plab hnyuv nqus (Witschi li al., 1992). Liposome encapsulation technology tseem txhim kho kev nqus los ntawm cov tshuab hauv qab no:
Cov hauv paus ntsiab lus:
- Cov phospholipid bilayer tiv thaiv cov khoom xyaw nquag los ntawm kev puas tsuaj los ntawm kev ua kom zom zom mov (Keller li al., 2018);
- Ncaj qha nkag mus rau hauv cov txheej txheem hluav taws xob los ntawm cov hnyuv kab mob plab zom zaws cov nyhuv thawj cov nyhuv nyhuv ntawm daim siab (2018);
- Cov ntaub ntawv pov thawj kuaj mob: Liposome Npaj tuaj yeem nce ntshav glutathione qib los ntawm 30% (Richie li al., 2015).
III. Ua tau zoo ntawm glutathione
1.Antioxidant thiab anti-laus
Txo cov oxidative kev ntxhov siab marer {{} hodg ({} hydroxydeeoxyguanosine) (Richie li al., 2015);
Ua kom cov nrf2 txoj kev thiab Upregulates Superoxide dismutase (sod) kev ua (SU li al., 2013).
2.Lawm tiv thaiv
Txhim kho cov hauj lwm ua haujlwm hauv cov neeg mob tsis muaj cawv muaj rog: Alt Theem poob qis ntawm 29% (Hagen li al., 2002);
Ua kom nrawm kho cov siab puas tsuaj los ntawm acetaminophen lom (wu li al., 2004).
3.Chronic kis tau
Txhim kho cov insulin rhiab rau cov neeg mob uas muaj ntshav qab zib hom 2 (SAMIMI li al., 2016);
Kev ncua lub cev muaj zog ua haujlwm tsis zoo rau cov neeg mob uas ua phem rau cov neeg ua yeeb ncuab (Hauser li al., 2009).
4.Heavy hlau detoxification
Tseem ceeb tshaj qhov tso zis ua paug ntawm cov hlau hnyav xws li cov hmoov txhuas thiab mercury (aposhian li al., 1995).
IV. Muaj cov pej xeem thiab kev tshawb fawb siv cov lus pom zoo
Cov neeg muaj feem:
Cov pab pawg kev cuam tshuam oxidative oxidative (xws li cov neeg haus luam yeeb, ntshav qab zib);
Cov neeg mob muaj lub siab ua haujlwm txawv txav (yuav tsum tau siv nyob rau hauv tus kws kho mob);
Pab phiaj xwm kev siv:
Dosage: {250-500 ml \/ hnub (Liposomal Dosage Daim Ntawv) (Keller li al., 2018);
Kev sib koom ua ke ntxiv: sib xyaw ua ke nrog n-acetylcalyseine (NAC) tuaj yeem txhim kho hluavtaws hluavtaws (ZEMBRON-LACNY li al., 2014).
Ntawv Sawv cev
- Aposhian, HV, thiab AL. (1995). Tso cai rau Mercury Tom qab thawj coj ntawm 2, {2}}}}}}}} sulfonic acid: corrugonic acid: corrugonic acid: sib txheeb nrog cov qhab nia amalgam. FaseB phau ntawv xov xwm, 9 (7), A506.
- Tsim, HJ, thiab Al. (2009). Glutathione: Txheej txheem cej luam ntawm nws cov cwj pwm tiv thaiv, ntsuas kev ntsuas, thiab biosynthesis. Molecular yam ntawm cov tshuaj, 30 (1-2), 1-12.
- Hagen, TM, thiab AL. (2002). Txoj hmoo ntawm glutathione nyob rau hauv kev laus ra siab. Dawb radical biology thiab tshuaj, 33 (10), {3}}.
- Keller, BC, et al. (2018). Liposomal glutathione ntxiv txhawb cov xov tooj redox sab hauv tsev. Redox Biology, 17, 246-256.
- Richie, JP, thiab Al. (2015). Randomized tswj kev sim ntawm qhov ncauj glutathione txhawb nqa lub cev khw ntawm glutathione. Xov Xwm European ntawm khoom noj khoom haus, 54 (2), 251-263.
- Wu, G., thiab Al. (2004). Glutathione metabolism thiab nws cuam tshuam rau kev noj qab haus huv. Phau Ntawv Xov Xwm ntawm Khoom Noj, 134 (3), 489-492.
DISCLAIMER: Cov ntawv sau saum toj no yog txhua yam los ntawm kev tshawb fawb cov ntaub ntawv tshawb fawb thiab Is Taws Nem thiab tsis tau raug soj ntsuam los ntawm cov chaw muaj tswv yim hauv tebchaws. Kab lus no tsis yog xav kuaj, kho, kho lossis tiv thaiv ib tus kabmob. Yog tias muaj kev cuam tshuam lossis tsis nkag siab, thov hu rau peb kom muab tshem tawm. Ua tsaug.