I. Cov tswv yim tseem ceeb ntawm NAD +
NAD +, tag nrho lub npe nicotinamide adenine tinucleotide, yog tus tseem ceeb coenzyme tam sim no nyob rau hauv txhua txhua lub cev muaj sia. NAD + si ntau lub luag haujlwm hauv cov hlwb thiab yog ib qho kev ua haujlwm tsis tseem ceeb, suav nrog cov kev cai hauv lub zog, thiab kev tswj hwm kev ruaj ntseg ntawm kev ruaj ntseg ntawm qhov chaw nyob hauv nruab nrab.
Tus qauv tshuaj ntawm NAD + muaj peb ntu loj: Tsis tas li ntawd yog cov vitamins acid, yog ib qho khoom qab zib (txiv vitamin) Ob tus khub molecules tau txuas nrog los ntawm phosphoditer sib cog lus los ua tus qauv cinnleoto.
'Cov. Kev ua tau zoo ntawm NAD + raws li kev noj zaub mov ntxiv
1. Txhim Kho Lub Zog Metabolism
NAD + yog cov khoom tseem ceeb hauv mitochondrial zog metabolism.[2]Nws tuaj yeem txhawb cov oxidorylation txheej txheem ntawm cov as-ham xws li cov piam thaj thiab cov roj ntsha hauv mitochondria, yog li ua kom lub pob tw (Adenosine Triphosphate) los muab lub zog rau cov hlwb. Ntxiv NAD + pab txhim kho mitochondrial muaj nuj nqi, txhim kho cov metabolism diamond, thiab daws kev qaug zog.
2. Los tiv thaiv kev laus
Cov kev tshawb fawb tau pom tias NAD + muaj cov cuam tshuam tseem ceeb rau kev tawm tsam kev laus. Los ntawm kev nce NAD + qib, lub ntev protein sirtuins tuaj yeem ua kom tiav, tiv thaiv Mitochondrial muaj nuj nqi, thiab tswj hwm cov kev ruaj khov. Tsis tas li ntawd, NAD + tuaj yeem txhawb nqa cell autophagy, tshem tawm cov hlwb senterescent, thiab tswj cov haujlwm ntawm cov ntaub so ntswg thiab cov plab hnyuv siab raum.[3]
3. Tiv Thaiv Cov Mob Plawv
NAD + muaj cov nyhuv tiv thaiv ntawm cov hlab plawv. Ntxiv NAD + tuaj yeem txo qhov kev ntxhov siab oxidative, txo cov kev puas tsuaj endothel hauv siab, thiab txhim kho vasodilation.[4]Nyob rau tib lub sijhawm, NAD + tseem tuaj yeem tswj cov kua dej ntshav thiab txo qhov kev pheej hmoo ntawm atherosclerosis.
4. Txhim Kho Lub Ntsia Lub Ntsia Ua Haujlwm
Nad + ua lub luag haujlwm tseem ceeb hauv lub paj hlwb. Ntxiv NAD + tuaj yeem nce lub zog theem hauv cov hlab ntsha, txhim kho cov phiajcim mob hlwb, thiab txhim kho kev ua haujlwm zoo nkauj. Tsis tas li ntawd, NAD + tuaj yeem txhawb cov proliferation ntawm neural qia hlwb thiab kho cov ntaub so ntswg puas.[5]
5. Txhim kho kev tiv thaiv
NAD + kuj tseem ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv kab mob. Ntxiv NAD + tuaj yeem txhim kho kev ua haujlwm ntawm lub cev tiv thaiv, txhim kho lub cev tsis kam, thiab tiv thaiv tus kab mob.[6]
III. Lub ntsiab
Hauv cov ntsiab lus, -Nicotinamide Adenine DinucleTide ITabiovas kev tiv thaiv, txhim kho kev ua haujlwm ntawm lub zog xws li kev ua haujlwm thoob plaws, txhim kho kev ua haujlwm ntawm lub zog, txhim kho kev ua haujlwm ntawm lub zog, thiab txhim kho kev tiv thaiv. Tsim nyog txhawb nqa NAD + tuaj yeem pab txhim kho kev loj hlob thiab kev noj qab haus huv lub cev. Txawm li cas los xij, nws yuav tsum tau sau tseg tias NAD + cov tshuaj pab tsis yog Omnipotent. Kev noj haus tsim nyog thiab tswj cov cwj pwm zoo yog lub rooj tog ntawm kev noj qab haus huv. Thaum xaiv NAD + cov tshuaj pab, thov ua raws cov kev qhia tshaj lij los xyuas kom muaj kev nyab xeeb thiab ua haujlwm zoo.
Ntawv Sawv cev
- Molecule ntawm lub lim tiam Archive: nicotinamide adenine cinnucleotide. Miskas Asmeskas cov neeg siv tshuaj (ACS). [{2024-08-22].
- Amjad S, Nisar S, Bhat Aa, Shah ar, Fakho K, HaraGa P, Rockga P. Lub Luag Haujlwm ntawm NaBega P. Lub Luag Haujlwm ntawm NaBega hauv kev tswj hwm ntawm tes thiab cov duab liab taw. Mol metab. 2021 Jul; 49: 101195. DOI: 10.1016 / j.Molmet.2021.101195. EPUB 2021 FEB 17. PMID: 33609766; PMCID: PMC7973386.
- Covarrubias AJ, Pej-siab R, Grzio A, Verdin E. Nad + metabolism thiab nws cov luag haujlwm hauv cov txheej txheem cellular thaum laus. Nat Rev Mol Mol Mol BIOL. 2021 Feb; 22 (2): 119-141. doi: 10.1038 / s 41580-020-00313- x. EPUB 2020 Dec 22. Pmid: 33353981; PMCID: PMC7963035.
- Abdellatif M, Bugger H, Kroemer G, li al. Nad + thiab Vascular Tysfunction: los ntawm kev siv tshuab los kho lub sijhawm zoo [J]. Phau ntawv sau txog lipid thiab atherosclerosis, 2022, 11 (2): 111.
- Zhars Y, Zhang Y, Zheng Y, Zhang Y, Wang XJ, Wang X, FU J, FU J, FU J, J NeuroinFramation. 2021 Sep 16; 18 (1): 207. DOI: 10.1186 / s 12974-021-02250-8. PMID: 34530866; PMCID: PMC844444613.
- Shang J, Smith Mr, Anmangandla A, Lin H. Nas +- Siv cov enzymes hauv kev tiv thaiv kab mob. Biochem J. 2021 Dec 10; 478 (23): 4071-4092. DOI: 10.1042 / bcj20210181. Erratum hauv: Biochem J. 2022 Mar 18; 479 (5): 581-582. DOI: 10.1042 / bcj -2021-0181 c} c} 17}} cor. PMID: 34871367; PMCID: PMC8718269.
DISCLAIMER: Cov ntawv sau saum toj no yog txhua yam los ntawm kev tshawb fawb cov ntaub ntawv tshawb fawb thiab Is Taws Nem thiab tsis tau raug soj ntsuam los ntawm cov chaw muaj tswv yim hauv tebchaws. Kab lus no tsis yog xav kuaj, kho, kho lossis tiv thaiv ib tus kabmob. Yog tias muaj kev cuam tshuam lossis tsis nkag siab, thov hu rau peb kom muab tshem tawm. Ua tsaug.