Ovarian premature failure (POF), tseem hu ua lub zes qe menyuam ntxov ntxov tsis txaus (POI), hais txog kev poob ntawm zes qe menyuam ua haujlwm hauv cov poj niam ua ntej hnub nyoog 4 xyoos 0, tus cwj pwm los ntawm kev ua tsis tiav ntxov ntawm zes qe menyuam follicles lossis cessation ntawm follicular kev loj hlob. . POF yog tus cwj pwm los ntawm qib qis ntawm cov tshuaj hormones thiab qib siab ntawm gonadotropins. Kwv yees li ntawm 1% ntawm cov poj niam hnub nyoog qis dua 40 xyoo thiab 0.1% ntawm cov poj niam hnub nyoog qis dua 30 xyoo tau ntsib tus mob no. Cov tsos mob hauv tsev kho mob muaj xws li kev coj khaub ncaws tsis tu ncua, kev yug me nyuam nyuaj, kub hnyiab, hmo ntuj tawm hws, qhov chaw mos dryness, irritability, thiab concentration nyuaj. Cov ua rau POF muaj xws li chromosomal defects, toxin exposure, thiab autoimmune kab mob, tab sis feem ntau, etiology tseem tsis paub. Rau cov poj niam muaj hnub nyoog yug me nyuam nrog mob qog noj ntshav, kev puas tsuaj rau gonadal muaj nuj nqi los ntawm kev kho mob thiab kev kho hluav taws xob yog qhov tseem ceeb ntawm POF. Yog li ntawd, POF kev kho mob yog qhov zoo rau kev rov ua kom muaj menyuam thiab tswj kev coj khaub ncaws. Cov tshuaj siv tshuaj khomob ib txwm siv, cyclophosphamide (CTX) thiab busulfan (BU), feem ntau yog siv los tsim POF tsiaj qauv raws li lawv cov kev ua me nyuam loj heev.
Kev nkag siab ntawm resveratrol cas 501-36-0
Tus resveratrol cas no yog 501-36-0. Resveratrol (RES) cas 501-36-0 yog ib qho tshuaj lom neeg cog qoob loo uas muaj dav hauv txiv hmab txiv ntoo, mulberries, thiab lwm yam nroj tsuag. Nws tuaj yeem kho ntau yam teebmeem tshuaj, suav nrog tshuaj tiv thaiv qog, tiv thaiv kab mob, tiv thaiv kab mob, antioxidant, tiv thaiv cell, thiab tiv thaiv apoptotic teebmeem. Kev sib sau ntawm dysfunctional follicles ntsig txog lub zes qe menyuam tuaj yeem ua rau cov txheej txheem laus. Resveratrol cas tuaj yeem tshem tawm ROS ntau ntxiv. Tom qab tshem tawm ntau tshaj ROS nyob rau hauv zes qe menyuam ntawm Sprague-Dawley nas, follicular hlwb tau pom tias tsis muaj cisplatin oxidative toxicity. Tsis tas li ntawd, RES tuaj yeem txhim kho cov qauv follicular los ntawm kev txo qis LH, LH / FSH piv, thiab TNF- qib. Cov kev tshawb fawb saum toj no qhia tias RES tuaj yeem txhim kho lub zes qe menyuam ntxov ntxov los ntawm kev txhim kho ib puag ncig ntawm follicles thiab fgcs, yog li txhawb nqa lawv txoj sia.
Kev tiv thaiv ntawm resveratrol cas 501-36-0 ntawm tus naj npawb thiab kev loj hlob ntawm cov follicles tshwm sim los ntawm cyclophosphamide hauv POF qauv
Ob koob tshuaj resveratrol cas 501-36-0 (20mg / kg thiab 40mg / kg) tau muab tshuaj los ntawm gavage rau 28 hnub. Tom qab ntawd, tus nas qhov hnyav, qhov hnyav ntawm zes qe menyuam, thiab zes qe menyuam / nas txheeb ze qhov hnyav raug xam cais. Cov txiaj ntsig tau pom tias piv nrog pawg tswj hwm, qhov hnyav ntawm POF nas poob qis, thaum qhov hnyav ntawm cov nas hauv 20mg / kg thiab 40mg / kg RES pawg tau siab dua li hauv pawg POF. Peb kuj suav tag nrho qhov hnyav ntawm nas txhua lub lim tiam. POF qauv nas muaj qhov kev loj hlob qeeb, tab sis cov resveratrol cas 501-36-0 pab pawg muaj kev loj hlob sai. Txawm hais tias nws staining tau pom tias cov follicles hauv pawg RES-kho tau tsawg dua li hauv cov zes qe menyuam ntawm cov nas, cov follicles ntawm txhua qib tau pom nyob rau hauv 20 thiab 40 mg / kg resveratrol cas pab pawg kho mob, tab sis ob peb
follicles tau pom nyob rau hauv pawg POF. Kev suav cov naj npawb ntawm cov follicles hauv txhua theem tau pom tias qhov piv ntawm cov hauv paus follicles rau thawj cov follicles tau nce hauv pawg RES-kho tau piv nrog POF pawg. Tom qab kev kho mob nrog resveratrol cas, tus naj npawb lossis qhov sib piv ntawm cov follicles raug txo qis, tshwj xeeb tshaj yog nyob rau hauv 40mg / kg RES pawg, thiab qhov piv ntawm cov follicles qub tau nce zuj zus nrog nce RES concentration piv nrog POF pawg. Tsis tas li ntawd, cov lus qhia theem ntawm cov kab mob los yog cov cim cim tshwj xeeb Muh thiab Oct4 hauv pawg RES tau rov qab zoo dua piv nrog POF pab pawg, qhia tias RES muaj kev tiv thaiv tus lej thiab kev loj hlob ntawm cov follicles hauv POF nas.