Ntau thiab ntau cov pov thawj qhia tau hais tias neuroinflammation yam ntxwv los ntawm lub cev tiv thaiv kab mob infiltration, mast cell thiab glial cell ua, thiab zus tau tej cov inflammatory mediators nyob rau hauv lub peripheral thiab central lub paj hlwb plays lub luag hauj lwm tseem ceeb nyob rau hauv induction thiab kev kho mob ntawm o. Palmitoylethanolamide yog N-acylethanolamide thiab lipid nrog cov tshuaj tiv thaiv kab mob. Txawm li cas los xij, tsawg heev paub txog nws cov nyhuv analgesic hauv qhov mob ntev.
Nkag siab Palmitoylethanolamide
Palmitoylethanolamide bulk hmoov yog ib qho endogenous fatty acid amide nrog cov qauv tshuaj ntawm N-(2-hydroxyethyl) esadecanamides thiab raug suav hais tias yog cov khoom siv tus kheej. Tshwj xeeb, nws yog lub npe hu ua cov tshuaj tiv thaiv kab mob vim kev txo qis ntawm cov neeg nruab nrab tso tawm los ntawm cov hlwb mast, monocytes, thiab macrophages. Tsis ntev los no, nws tau pom tias palmitoylethanolamide muaj lub peev xwm muaj peev xwm los hloov cov txheej txheem nyuaj uas cuam tshuam nrog o, pruritus, neuropathic, thiab qhov mob nociceptive.
Nkag siab txog cov tshuaj tiv thaiv kab mob thiab tshuaj tua kab mob ntawm Palmitoylethanolamide
Palmitoylethanolamide feem ntau suav hais tias yog koom nrog hauv endogenous tiv thaiv mechanisms tshwm sim los ntawm ntau hom kev puas tsuaj los yog endogenous o thiab nociceptive fiber stimulation. Nws muaj N-acylethanolamide thiab lipids thiab paub tias muaj cov tshuaj tiv thaiv kab mob. Tsis zoo li nws cov tshuaj tiv thaiv kab mob, nws cov nyhuv analgesic hauv qhov mob ntev tsis paub ntau. Ntau cov kev tshawb fawb tau pom tias palmitoylethanolamide tuaj yeem txo qis qhov mob uas tsis muaj kev phom sij rau tib neeg. Hauv kev sim tsiaj, palmitoylethanolamide tuaj yeem muaj kev tiv thaiv kab mob thiab tshuaj tua kab mob hauv qee yam mob ntsig txog mob thiab mob.
Palmitoylethanolamide muaj cov teebmeem analgesic dav thiab cov teebmeem no tau raug sim hauv ntau hom kev mob. Nws alleviates tus cwj pwm mob tshwm sim los ntawm formalin, magnesium sulfate, carrageenan, paj hlwb loj hlob, thiab turpentine roj. Tsis tas li ntawd, palmitoylethanolamide tau tshaj tawm tias inhibit qhov mob hypersensitivity tom qab sciatic paj ligation hauv tus qauv mob neuropathic. Palmitoylethanolamide tuaj yeem koom nrog hauv kev tswj hwm endogenous ntawm nociception vim tias nws cov nyhuv analgesic tshwm sim sai thiab ua ntej nws cov nyhuv anti-inflammatory. Txawm li cas los xij, qhov tshwj xeeb analgesic mechanism ntawm palmitoylethanolamide tam sim no tsis meej.
Thaum monoiodoacetic acid (MIA) nyob hauv zos txhaj rau hauv kev sib koom ua ke, nws ua rau mob sai sai, cuam tshuam cov metabolism ntawm chondrocytes, thiab tom qab ntawd ua rau pob txha mos degeneration. Tsis tas li ntawd, MIA-induced nas osteoarthritis zoo ib yam li tib neeg osteoarthritis nyob rau hauv cov nqe lus ntawm pob txha mos thiab skeletal pathological nta thiab yuav siv tau raws li ib tug minimally invasive tsiaj qauv.